Silva, Rodrigo G. Nogueira, Caio L. Nienstedt, Thiago C. Trial registration ClinicalTrials. Department of Health and Human Services. Although mechanical ventilation provides essential life support, it can worsen lung injury[ 6 ]. All other study committees report to the TSC.
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Mechanisms of ventilator-induced lung injury include regional alveolar overdistention, repetitive alveolar collapse with shearing atelectraumaand oxygen toxicity[ 78 ]. Accepts Healthy Volunteers:. The TSC members are investigators trained in designing and conducting randomized clinical trials, intensivists, respiratory therapists, and pulmonologists experienced in conducting multicenter randomized studies on ARDS.
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|Save this study. Additional information Competing interests The authors declare that they have no competing interests.
Eligibility Criteria. Study was early terminated due to problems enrolling adequate number of patients. Criteria to diagnose failure in spontaneous ventilation test are presented in Table 4.
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Trial registration ClinicalTrials. Giuberti, Melissa C. Mezzaroba, Thiago S. The TSC is responsible for the overall study supervision, assisting in developing the study protocol and preparing the final manuscript.
Details of the centers which accepted to participate in the trial at the time of this manuscript submission are given in the Appendix.
Actual Study Completion Date :. Therefore, the primary results of the trial will be published under the name of ART Investigators.